The Relationship Between Thymosin β4 and Vitamin D3 in Systemic Lupus Erythmatosus Patients
Noor H. Al-Hashimy 1, Hadi R. Al-Masudi 2 and Mohammed S. Mahdi 3
1 Department of Biology, College of Science, University of Karbala, Iraq.
2 Department of Clinical Laboratories, College of Applied Medical Sciences, University of Karbala, Iraq.
3 Imam Hussein Medical Hospital, The City of Karbala, Karbala Health Directorate, Karbala, Iraq.
Objectives: The aim of the current study is to focus of the relationship
between thymosin β4 and vitamin D3 in systemic lupus erythmatosus
Methods: This study included sixty of systemic lupus erythematosus
patients that diagnosed by clinic specialists by using (SLEDAI) taken from
(Al-Hussein Medical City/Kerbala / IRAQ). During the period from
January 2015 to December 2016. Control group of 30 healthy persons who
matched in gender and age with patients, and haven’t history for this
disease. The majority of the SLE patients were female 95% , the ratio of
female male 19:1. The age of SLE patients was ranging from (7-65)
compared with healthy control group as a seem in age.
Results: The result shows a significant decreasing in concentration of
thymosin β4, vitamin D3 and circulating complement factors (C3,C4) in
active SLE patients compare with healthy control while significant increase
in concentration of ANA and ds-DNA antibodies and disease activity
measured using the SLE disease activity index (SLEDAI).
Conclusion: Positive relationship between level thymosin β4 and
concentration vitamin D3. There is an inverse relationship between
Thymosin β4 and disease activity index of SLE.