STUDY OF USING KOJIC ACID AS ANTICANCER IN DIFFERENT CONCENTRATION TO TREATMENT CANCERED RATS Rattus norvegicus BY CYCLOPHOSPHAMIDE

Jasim A. Abdullah
Clinical Laboratories Department, Applied Medical Sciences College, Karbala University ,Karbala , Iraq.

ABSTRACT
Objective: This study was conduct to investigate effect of kojic acid to treatment ofcancered rate. Methods: Different concentration 0.5, 1, 2 mg/kg used as treatment through 30 days in some histological and functional criteria in cancered rats Rattus norvegicus by cyclophosphamide and the parameters that studied were WBC, PCV, HB , platelets , AST, ALT, and Bilirubin . Results: The result showed there is significant difference in blood parameters (WBC , platelets) at P≤ 0.01 and there is no significant difference in (HB , PCV) when compared with control group in addition T3, T4 , TSH levels showed no significant difference in all group of rats that treated with kojic acid when compared with control group at P≥ 0.01 also showed significant difference in ALT, AST, Bilirubin when compared with control group at P≤ 0.01 that lead to increase of ALT, AST, Bilirubin related to increase with kojic acid and then we showed significant change in the liver and kidney tissues in concentration 2 mg/kg of kojic acid when compared with control group and finally. Conclusion: We can consider the kojic acid is very good substance may be useful as antibiotic or antioxidant in some researches because it is very safe on the body .