Immunohistochemistry of Detection HER2 on Breast Cancer in Basra City

Rana SH. Ismail 1, Awatif H. Issa 2 and Abdulelah A. Almayah 3
1 Department of Biology, College of Science, University of Basra , Basra, Iraq.
2 Department of Pathological Analysis, College of Science, University of Basra, Basra, Iraq.
3 College of Pharmacy, University of Basra, Basra, Iraq.

ABSTRACT
Objectives: Breast cancer is the most typical style of cancer in females.
The human epidermal growth factor receptor 2 (HER2) is a potential
molecular target in breast carcinoma and it is abundantly expressed in this
type of cancer and other cancers. The present study target is detection about
HER2 in breast cancer patients of Basrah city.
Methods: Fifty patients were registered and diagnosed as breast cancer
disease patients and without breast cancer. Immunohistochemistry was
carry out to evaluate the distribution of HER2 by using positive charge
slide.
Results: The result was screen about HER2 status in female patients with
breast cancer in Basra city / Iraq, and the ages female patients with breast
cancer ranged were from 20 to 60 years. The HER2 status reported there
was no-significant difference in age groups of cancer status, while there
was a significant association between stage I stage II and III of HER2 status
and was (P= 0.001).
Conclusion: This study review the role of HER2 diverse cancers, and
diagnostic by immunohistochemistry assay. Immunohistochemistry is a
well-established ancillary technique to facilitate the diagnosis of infectious
and neoplastic processes and help to diagnosis and as a proof to
appropriate therapy.