ISSN: 2520-5234

STUDY OF USING KOJIC ACID AS ANTICANCER IN DIFFERENT CONCENTRATION TO TREATMENT CANCERED RATS Rattus norvegicus BY CYCLOPHOSPHAMIDE

Abstract

Objective: This study was conduct to investigate effect of kojic acid to treatment ofcancered rate.

Methods: Different concentration 0.5, 1, 2 mg/kg used as treatment through 30 days in some histological and functional criteria in cancered rats Rattus norvegicus by cyclophosphamide and the parameters that studied were WBC, PCV, HB , platelets , AST, ALT, and Bilirubin .

Results: The result showed there is significant difference in blood parameters (WBC , platelets) at P≤ 0.01  and there is no significant difference in (HB , PCV) when compared with control group in addition T3, T4 , TSH levels showed no significant difference in all group  of  rats  that treated with kojic acid when  compared with control group at P≥ 0.01 also  showed significant difference in ALT, AST, Bilirubin when compared with control group at P≤ 0.01 that lead to increase of ALT, AST, Bilirubin related to increase with kojic acid and then we showed  significant change in the liver and kidney tissues in concentration 2 mg/kg of kojic acid  when compared with control group and  finally.

Conclusion: We can consider the kojic acid is very good substance may be useful as antibiotic or antioxidant in some researches because it is very safe on the body .

Editor in Chief
Dr.Alaa Abdul Hussein Al-Daamy

009647801273238
009647729520918

alaa.sjomr@gmail.com ; sjomr.journal@gmail.com

Editor in Chief
Dr.Alaa Abdul Hussein Al-Daamy

009647801273238
009647729520918

alaa.sjomr@gmail.com ; sjomr.journal@gmail.com

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