A Histological Study To Investigate The Effectiveness Of Sacchromyces cerevisiae Yeast In The Reduction Of Aflatoxin B1 Toxicity In White Rat Animals


Huda Abdul Ridha Abdullah 1
1 Environmental health Department, Applied Medical Sciences College, Karbala University, Iraq.


Objective: The study included the use of bio-method and environmentally friendly effective in the reduction of the toxicity of Aflatoxin B1. Methods: A study of the effect of Sacchromyces cerevisiae yeast in the effectiveness of AflatoxinB1 included the preparation of three groups of white rat animals include Negative control Is represented four lab animals treated with Aflatoxin only ( concentration 100μg /kg w.b. ) , Positive control Is represented four animals treated with normal saline only ( 1 ml / kg w.b. )and four animals treated with mixture of yeast and toxin B1 with 1ml/ kg w.b. for 48 h , The animals were then anatomy by opening the abdominal cavity and taking organs (liver, intestines, kidneys, spleen) into study histological changes. Results: The results of the histological study in the treatment of toxin with yeast was the safety of the tissues studied from the injury and were normal compared to the treatment of control while the treatment of toxin only, The study showed injuries and histological changes represented by necrosis , hemorrhage and vascular congestion of all studied organs. Conclusion: Sacchromyces cerevisiae yeast provided complete protection for the organs under study (liver, intestine, spleen and kidney ) of the harmful effect of AflatoxinB1.